Large Intra-Age Group Variation in Chromosome Abnormalities in Human Blastocysts

Research Question: Is maternal age only a gross predictor of chromosome abnormalities in human embryos? Design: Here, we evaluated the less-studied variation abnormality rates embryos patients within same group. Patients undergoing IVF and PGD for chromosomal ~127 different clinics were included. PGT-A analysis was performed by single reference laboratory using array CGH or NGS. To get an estimate range observed, aCGH NGS data studied both independently together. Results: The overall results showed typical increase aneuploidy with advancing (AMA) but extensive variability each Conclusions: Increasing has been demonstrated live births, unborn fetuses, oocytes. In contrast, post-meiotic other that might lead to mosaicism, polyploidy haploidy, are commonplace (around 30%), regardless age. Here conclude is embryos. contrast existing standard offering AMA patients, high rate extreme may warrant further cycles even younger groups, especially if history increased levels evident. Furthermore, better indicators needed determine which at higher risk producing aneuploid